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KMID : 0356919920250030503
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Korean Journal of Anesthesiology
1992 Volume.25 No. 3 p.503 ~ p.508
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The Change of Activated Coagulation Time During Cardiac Surgery
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Abstract
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Since it's introduction by Hattersley in 1966, the acivated coagulation time(ACT)is widely used as a indicator of coagulation status of a patient during caridiac surgery. There have been many studies about the pre-heparin and
post-heparin(post-protamine) ACT's, but the results vary. Comparisons of baseline ACT to postprotamine ACT revealed that there were studies which showed postprotamine ACT significantly above baseline ACT, while others were opposite. So we checked
baseline ACT at three different point of time:1) before anesthetic induction: 2) after anesthetic induction; 3) after sternotomy. We also checked postheparin and postprotamine ACT, and compared it with baseline ACT's The postprotamine ACT showed
significant increase compared with the preinduction and postinduction ACT and no significant differences between preheparin ACT's We think that heat hemodilution and hypothermia might have influenced on the postprotamine ACT.
It seems that baseline ACT can be measured anytime before the injection of heparin. But there are many factors which can influence the measurement of the ACT. Therefore, cares must be taken in the interpretating the result of ACT, considering the
factors of ACT variability and clinical observations of blood coagulability.
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KEYWORD
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